| Pair Name | Pulsatilla saponin D, Temozolomide | ||
| Phytochemical Name | Pulsatilla saponin D (PubChem CID: 11650910 ) | ||
| Anticancer drug Name | Temozolomide (PubChem CID: 5394 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Pulsatilla saponin D, Temozolomide | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->Triggering caspase-independent cell death | |||
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| Up-regulation | Expression | MAP1LC3B | hsa81631 | |
| Up-regulation | Expression | SQSTM1 | hsa8878 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| Up-regulation | Expression | CTSB | hsa1508 | |
| In Vitro Model | T98G | Glioblastoma | Homo sapiens (Human) | CVCL_0556 |
| U-87MG ATCC | Glioblastoma | Homo sapiens (Human) | CVCL_0022 | |
| Result | SB365 inhibits autophagic flux and induces caspase-independent cell death in GBM cells in a manner involving cathepsin B and mainly reactive oxygen species, and its use in combination with temozolomide shows promise for the treatment of GBM. | |||
| No. | Title | Href |
|---|---|---|
| 1 | SB365, Pulsatilla Saponin D Induces Caspase-Independent Cell Death and Augments the Anticancer Effect of Temozolomide in Glioblastoma Multiforme Cells. Molecules. 2019 Sep 5;24(18):3230. doi: 10.3390/molecules24183230. | Click |
